This meme might be found funny or clever because it uses an image of a house with a roof that looks like it has eyes and a mouth (due to the windows and discoloration pattern), giving the impression that the house is 'stoned' or 'high'. The term 'hotbox' refers to smoking cannabis in an enclosed space, causing it to fill with smoke. The house appears as if it has been a part of this activity, which is an amusing anthropomorphism.