The meme humorously combines characters from the animated movie 'Monsters, Inc.' with a scene from the horror genre, likely 'The Exorcist', where a character is being levitated above a bed in a typical possession scenario. The juxtaposition of the light-hearted, friendly monsters with a tense and scary scene creates an ironic and comical contrast, as the monsters appear shocked and scared, which is a reversal of their roles in the animated film where they are typically the ones doing the scaring.